Fairbrother KJ, Heasman PA: Anticalculus agents. J Clin Periodontol ; the research associated with the development of anticalculus agents and to evalu-. Request PDF on ResearchGate | Anticalculus agents | Most dentifrices and some mouthrinses now contain 1 or more active anticalculus agents to achieve. With the help of antiplaque and anticalculus agents. Chemical plaque control – Rationale. Gingivitis & periodontitis are highly prevalent diseases and.
|Published (Last):||13 May 2014|
|PDF File Size:||1.47 Mb|
|ePub File Size:||18.88 Mb|
|Price:||Free* [*Free Regsitration Required]|
Anti-plaque and Anti-calculus Oral Care Product Testing
As used herein, the term “phosphate” denotes phosphates and polyphosphates including pyrophosphates. To optimize stability of the final composition a pH of at least about 7. Delivery of the biphenol compound is typically measured using a model system of delivery to saliva-coated hydroxyapatite discs, as described anticalcculus further detail below.
Evaluating how your products and services meet and exceed quality, safety, sustainability and performance standards. At the afents of the test the residual biofilm is dissolved in acid and tested for calcium content using inductively coupled plasma – optical emission spectroscopy ICP-OES which is conducted in a Good Clinical Practice GCP compliant laboratory.
These silica abrasives are described in U. The numbers listed are weight percentages of the compositions. In aggents way, delivery of the antibacterial biphenol compounds is significantly improved thereby allowing increase in antiplaque activity of the oral composition or enabling a reduction in the amount of the antibacterial biphenol compound needed to achieve antiplaque activity.
During anticapculus, the pH is maintained at a minimum of pH 7. Intertek Clinical Research Services is licensed to handle and store human tissue under the Human Tissue Act and follows anticalcylus principles outlined within the act as well as complying with local ethical guidelines. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
Such mouthwashes and mouth sprays may also include an antiplaque agent from about 0. When the oral composition is a toothpaste, preferably from about 0. Preferred topical, oral carriers provide the desired characteristics for mouthwashes, mouth rinses, mouth sprays, dental treatment solutions, toothpastes, dental gels, toothpowders, prophylaxis pastes, and the like.
During manufacture of a composition of this invention, the conditions for addition anticlaculus each component should be optimized such that the pH anticalcupus the mixture does not drop below formulation pH at any time during mixing of the ingredients.
Pyrophosphate is also an anticalculus agent and, likewise, has an unpleasant taste which worsens with increased pyrophosphate concentration. The pathogenic potential of calculus attributes scaling and root planing the central role in the successful maintenance of periodontal health.
Applicants have surprisingly anticalulus that certain ratios of zinc: After nine weeks, the person received dental prophylaxis and rinses for forty-five seconds twice daily with 15 ml of the composition of Example XIV. Bleaching agents can also be present in the oral compositions of this invention.
Additionally, the agent may be developed from Magnolia officinalis, such as a synthetic magnolol, honokiol, tetrahydromagnolol, tetrahydrohonokiol, propylmagnolol, propylhonokiol, isopropylmagnolol, isopropylhonokiol, butylmagnolol, or butylhonokiol which have demonstrated bactericidal properties against representative oral bacteria S.
This abstract may be abridged. Anti-plaque and anti-calculus laboratory testing for oral care products to evaluate anti-bacterial, anti-adhesion or enzyme agfnts agents or crystal growth inhibition agents.
Anti-plaque and Anti-calculus Oral Care Product Testing
Preparation for prevention of emission of mercury from amalgam fillings and method. When the oral composition is a mouthwash, typically from about 1 ml. They have also contributed to a variety of scientific papers in collaboration with many well-known clients and have presented posters at International scientific conferences. Calculus is the most common calcified deposit in the oral cavity that forms on teeth with a covering layer of viable plaque, and remains in close juxtaposition to the gingival and supporting tissues and generates concern in periodontal disease.
Inspection Validating the specifications, value and safety of your raw materials, products and assets. PV Country of ref document: While the addition sodium sulfate alone Formula 11 did not impact magnolol delivery, such delivery was slightly improved in the presence of Zinc oxide Formula Flick, Cosmetic and Toiletry Formulations, 2nd ed.
Also preferred is a zincxitrate: The oral care composition of claim 1, wherein the anticalculus agent consists essentially of a zinc ion source. This invention also involves methods for treating or preventing dental plaque, calculus, gingivitis, or malodor of the oral cavity comprising amdinistering to the oral cavity of a human or other animal a safe and effective amount of such compositions.
Country of ref document: Sodium lauryl sulfates, sodium lauroyl sarcosinate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of atnicalculus type. While there is no complete agreement on the route by which precipitated calcium and orthophosphate ultimately become the crystalline material called hydroxyapatite HAPit is generally agreed that at higher saturations above the critical saturation limit the precursor to crystalline HAP is an amorphous or microcrystalline calcium phosphate.
Suitable preservatives include methylparaben, propylparaben, benzoates and ethanol. If added, the antibacterial active ingredients it is desirable that the additive does not substantially detract from the efficacy and bioavailability of the tartar control agents or the active compound of the extract.
Suitable binders include, but are not limited to, natural gums such as gum karaya, gum arabic, and gum tragacanth; polysaccharide gums such as xanthan gum; and other natural products such as carrageenan; chemically abents natural products such as those based on cellulose esters, that is, carboxylmethylcellulose CMChydroxyethylcellulose HECand hydroxypropylcellulose HPC ; and synthetic binders such as polyvinylpyrrolidone; and water soluble salts of cellulose ethers such as sodium carboxymethyl anticalcuulus and sodium carboxymethyl hydroxyethyl cellulose.
Agengs humectants are sorbitol and glycerin; more preferred is sorbitol. Another aspect of this invention involves methods of treating or preventing mouth odor, dental plaque, calculus and gingivitis, by antiicalculus of compositions comprising a safe and effective amount of Actives, to tissues of the oral cavity. In fact, if anything, the addition of a zinc ion source such as zinc oxide to compositions according to the present invention improves the delivery of the biphenol compound.
Mixtures of abrasives may be used. Silica dental abrasives, of various types, can provide the unique benefits of exceptional dental cleaning and polishing performance without unduly abrading tooth enamel or dentin. Summary of the Invention This invention involves oral-care compositions agenta Need anticwlculus or have a question?
The dentifrice and water mixture is stirred continuously for at least 30 minutes to ensure the mixture is homogenous.
By carefully formulating zinc and pyrophosphate-containing compositions, it has been surprisingly found that the level of zinc in an oral composition can be increased, thus increasing the corresponding anticalculus effect, without greatly increasing the negative aesthetics of the composition. A method of preventing inhibition of oral uptake of a Magnolia antibacterial agent from an oral care composition of any of claims 1 to 9 comprising formulating the oral care composition without phosphate-containing anticalculus agents.
The compositions must be at a pH which is safe for contact with the tissues of the. The following are examples of agebts and dental rinse compositions of this invention and are made using conventinal processes. Certification Formally confirming that your products and services meet all trusted external and internal standards.